The scaling up of adsorption columns is a crucial step toward the removal of emerging pollutants from domestic and industrial wastewaters. In this study, a fixed-bed column to remove sulfamethoxazole packed with sugarcane bagasse was scaled up from laboratory (D-L = 2.2 cm) to pilot unit (D-P = 4.4 cm) using a scaling factor (K = 2). In addition to the basic similarity rules for scaling, three new criteria were proposed for the mass adsorbent, flow rate, and bed volume. Then, three lab-scale tests at flow rate of 5 mL/min and bed heights of 15, 25, and 35 cm were transferred to the pilot-scale column at flow rate of 20 mL/min and bed heights of 30, 50, and 70 cm, respectively. The breakthrough curves and the fixed-bed parameters (residence time t(R), saturation time t(s), adsorption capacity qe, volume of solution treated V-ef, and removal percentage \%R) obtained in both scales were compared to define their effect with the increase of scale. Finally, a mechanistic model was proposed to predict the breakthrough curves in both columns. The results exhibited that the breakthrough curves in the pilot-scale prolonged in time with higher breakthrough and saturation times than the laboratory breakthrough data. Additionally, t(R), t(s), and V-ef changed in function of the K value used: ts and t(R) doubled their value in the pilot column or t(R) P = K-tRL; Vef was eight times higher in the pilot column than the lab-column or V-efP = K-VefL(3); qe and \%R remained constant in both scales; these results were corroborated with the predicted breakthrough curves. Besides, the mechanistic model pre-dicted with great precision the breakthrough data in both scales (R-2 > 0.9), which means that the model can be used confidently for scaling up purposes. This study demonstrated new criteria which can be easily applied to scale up adsorption columns whit results that showed a correlation between both scales. (C)\& nbsp;2022 Institution of Chemical Engineers. Published by Elsevier Ltd. All rights reserved.