A new integrated methodology to estimate environmental impacts of bioethanol production from sugarcane bagasse was developed for Mexico. The methodology included five modelling phases: (i) a bibliometric analysis and systematic literature review using peer-review journals, and world citation databases; (ii) a simulation of the gasification process to produce bioethanol; (iii) a life cycle inventory gathered from simulation, literature and Ecoinvent data sources; (iv) a life cycle assessment (LCA) of the bioethanol production stages (raw material extraction, transportation, sub-product extraction, biofuel production, biofuel use in vehicles, and refinery construction and decommissioning), the cumulative energy demand, and water footprint; and (v) the analysis of the major environmental burdens.After a comprehensive searching in Web of Science and Scopus, 55 articles dealing with the state-of-art of the main research subjects for the time period 2008 - 2021 were compiled. The bioethanol production was simulated by using the Aspen Plus v11 software, where a yield of 0.42 L bioethanol per kg of bagasse was estimated for a production of 1,000 L/h and a purity of 98.6 \%. In response to the limitations observed in previous environ-mental evaluations conducted for the bioethanol production, the present LCA work was carried out from a robust cradle-to-grave perspective to quantify the major environmental burdens, and the cumulative energy demand and water footprints. Biofuel use in vehicles (70 \%) and biofuel production (25 \%) stages present the highest contributions for the GWP impact category, which was totally quantified as -26.7 kg CO2-eq/L. When a cradle -to-gate perspective was modelled, this amount was significantly reduced (-8.4 kg CO2-eq/L). For other impact categories evaluated, the highest contributions corresponded to the biofuel production (55 \% -95 \% for ADP, MAETP, EP, ODP, and POP), and raw material extraction stages (70 \% -100 \%: LC, HTP, FAETP and TETP). A comparison among previous LCA studies reported for gasification was discussed. This investigation constitutes the first study applied for bioenergy in Mexico from a successful coupling of LCA with process simulation as strategic tools for the evaluation of the environmental sustainability of bioethanol production.