The indication of substrates formulated with agro-industry residues for the production of mahogany seedlings (Swietenia macrophylla K.) can be a viable alternative to minimize production costs, since the substrate is one of the inputs of greatest investment for the formation of seedlings of good quality. The recommendation of formulation for this species are still scarce in the literature. Thus, the objective of this study was to evaluate the development of S. macrophylla seedlings on different substrates. The experiment was carried out at IFRO, Ji-Parana campus in a nursery at 50\% shade for 90 days. The substrates evaluated were formulated with organic compounds produced in nylon bags with a C:N ratio of 2:1, being: T1: commercial, T2: soil + sand (2:1), T3: soil + sand + bark of coffee/cassava husk/Bolivian leaf (2:1:1), T4: soil + sand + sugarcane bagasse/Bolivian leaf (2:1:1), T5: soil + sand + cassava husk/leaf of Bolivian (2:1:1), T6: soil + sand + coffee husks/Bolivian leaf (2:1:1) and T7: soil + sand + sugarcane bagasse/cassava husk/Bolivian leaf (2:1:1). The biometric variables evaluated were: height, collar diameter, dry mass and Dickson's Quality Index (DQI). A chemical evaluation of the substrates and leaves of the seedlings was carried out according to the methodology proposed by Embrapa. The experimental arrangement was in a completely randomized design, with seven treatments and 12 replications per treatment. All substrates tested met the recommendation in relation to the height of mahogany seedlings; substrates T1 and T3 showed higher potential. For the diameter of the collar, the substrates T3, T5 and T2 had values close to 5 mm, this being the ideal value for seedlings of good quality. As for the accumulation of dry mass, it was also verified that the plants cultivated in the treatments T1 and T3 also presented superior values than the other substrates. As for the IQD, the average values ranged between 0.16 and 0.45, with seedlings in the T4 substrate with a value lower than 0.20, which is recommended in the literature. The seedlings grown in T3 had the highest foliar values of N, P, K and S in relation to the other treatments evaluated. The S. macrophylla seedlings grown in substrate formulated with coffee husk and cassava compost (T3), as well as in commercial substrate (T1) met the recommended biometric, morphological and nutritional parameters.